Esch. coli endocarditis successfully treated with oral trimethoprim and sulphamethoxazole.

A 42-year-old patient was successfully treated for subacute bacterial endocarditis due to Esch. coli with oral trimethoprim and sulphamethoxazole. The treatment lasted nine months and was continued through a period of cholestatic jaundice superimposed on hepatic damage due to subacute bacterial endocarditis. There were no toxic effects attributable to the two antibacterials despite their prolonged administration.